Animaniacs

Premise Water Tower because they were seen as too zany. Several decades later, the trio escapes from the tower, interacting with Warner Bros. studio workers, including Ralph the Security Guard, archrival Dr. Otto Scratchansniff , and Hello Nurse. Pinky and the Brain are two genetically altered anthropomorphic laboratory mice who continuously plot and attempt to take over the world. The segments would begin with Brain asking, "Are you pondering what I'm pondering?" before Pinky would respond with a non sequitur . Slappy Squirrel is an octogenarian squirrel cartoon star paired with her nephew, Skippy . The Goodfeathers trio, Bobby, Pesto, and Squit, are pigeons from New York based on the characters Henry Hill , Jimmy Conway , and Tommy DeVito from Goodfellas (1990). Buttons is a pooch who risks his life to protect his four-year-old owner, Mindy . Rita and Runt are a homeless cat-and-dog duo, being dropped after the first season. Katie Ka-Boom is a teenager with a temper. Chicken Boo is a giant chicken who wishes to live among humans. Additional side characters include the Hip Hippos .