102 Dalmatians: Puppies to the Rescue

The player can choose the role of Oddball (voiced by Molly Marlette ) or Domino (voiced by Frankie Muniz in console versions ). Over the course of the game, the player has several opportunities to collect 'stickers' towards a virtual sticker book which can be accessed through the level menu. Various actions within the game will unlock stickers. Generally, there is a sticker for exiting every level, collecting 100 bones in each level and rescuing all the puppies in each level.

Each level has its own individual tasks which will also grant stickers: completing a chore, defeating a henchman and solving puzzles. There are six stickers per a level, excluding Cruella levels, which combine together with mini games for their own sticker image. The stickers are like puzzle pieces that create a realistic picture. Puppies to the Rescue is a 3-dimensional game with the ability to angle the camera in whichever direction will make it easiest for navigation.

The player must rescue the puppies by tumbling to break open the crates, and will also avoid and bark at enemy toys to short-circuit them, or tumble into them to smash them. Checkpoints within a level are places where the player will be sent back if a life is lost and are marked by a parrot named Waddlesworth, who will come and give them a ride around the level if they collect all the bones in the level, if they stand in the right place. If a toy hurts the player four times, a life is lost. If a checkpoint has not been reached before a life is lost, the player is sent back to the starting point.

Unlike the Game Boy Color version of the game where the toys are active after being broken, toys the players break stay broken. To regain lost health, the player can collect food in the levels and will also collect lives in them as well. Each level has a 'spirit animal friend' who will tell the player how to get through the level, and sometimes assign Oddball or Domino specific tasks to do in return for a reward or assistance. Certain levels also feature one of Cruella's three main henchmen from both films: Jasper and Horace from 101 Dalmatians , and Le Pelt from 102 Dalmatians .

Unlike enemy toys, they are invincible from normal attacks and the player must perform a certain task instructed by the level's animal friend in order to defeat them. After a specific number of levels has been completed, the player will face Cruella in a series of boss battles which will unlock a minigame to play upon completion.