The Amazing Spider-Man: Lethal Foes

After past defeats, Doctor Octopus escapes from prison and forces Curt Connors to help him. Connors attempts to use the Lizard serum to increase his power, but fails. Thus, Lizard becomes Octopus' new employee, while Octopus hires scientist Spencer Smythe to create the Spider Slayers and attack Spider-Man. Meanwhile, Spider-Man attempts to stop Beetle from robbing a bank, but is attacked by the Spider Slayers.

While Spider-Man manages to defeat the Spider Slayers, Beetle escapes and is subsequently hired by Octopus. Meanwhile, astronaut John Jameson is attacked by a red and black goo on his spaceship. Spider-Man defeats Beetle, and also defeats Lizard and uses the antidote on him, though it only takes him out of Octopus' control. Mysterio, hearing of Octopus' plans, traps Spider-Man in his headquarters, but Spider-Man defeats him and realizes he left a GPS that tracks Octopus' arms (given to Mysterio when he last helped Octopus).

After realizing someone is tracking him using the GPS, Octopus gains Mark II arms with more tentacles and forcefully transforms Alistair Smythe into a human/Spider Slayer hybrid. Meanwhile, Spider-Man tracks the GPS to Octopus' old arms, where he ambushed by Smythe. Later, Octopus sends Green Goblin after Spider-Man, and he chases him across the city. Venom ambushes the Goblin Glider, but Spider-Man stops him.

The Venom symbiote leaves Eddie Brock, who informs Spider-Man of Carnage's plan to destroy New York. Doctor Octopus suddenly attacks them, but his new arms are prototypes and begin to explode, causing Spider-Man to celebrate in triumph. Suddenly, the symbiotes come through a portal in the sky. Spider-Man defeats Carnage, who gets sucked back into space with the other symbiotes.

Spider-Man celebrates and is victorious. Later, J. Jonah Jameson reads a Daily Bugle article on Spider-Man’s victory, and attempts to write a paper which makes the symbiotes the heroes. Betty Brant scoffs and shreds the paper.