Tiny Toon Adventures: Buster Busts Loose!

This game features Buster Bunny in a side-scrolling adventure. It has three difficulty level settings: easy, normal, and hard (in game they are known as "Children", "Normal" and "Challenge" modes respectively) (except the Japanese version which only has easy and normal). Levels are significantly smaller in easy mode, and Buster only has one health container in hard mode, although extra containers can be collected by exploring the levels. The number of containers are reset after each level.

This is done to add more of a challenge in this mode. There are a total of six levels in the game when played normally (the fifth level is removed in easy mode). Buster's objectives vary from level to level, ranging from feeding Dizzy Devil so he stops destroying the school kitchen to defeating "Duck Vader". As is common for the era, the full ending is only accessed by finishing the game on hard (or normal in the Japanese release).

After completing each level, the player is given a chance to earn extra lives by playing a minigame, the type of which is determined by spinning a wheel based on the one seen in the episode, "The Wheel O'Comedy".